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Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
Jiabu Tang1, Zheng Yang2, Zhuo Wang2
1Department of Pathology, Guangdong Medical University, 1 Xincheng Road, Dongguan, 523808, China.
Background:
Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer.
Methods:
In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density.
Results:
These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer.
Conclusions:
These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer.
Trial Registration:
Gunagdong Medical University, PJ2013049.
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