Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.7K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.7K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

3.2K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
3.2K
Hormonal Regulation01:40

Hormonal Regulation

48.8K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.8K
Hormonal Regulation01:33

Hormonal Regulation

36.4K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.4K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

1.8K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.8K
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

3.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineered zwitterion-nanodelivery for precision targeting of brain metastases.

Nature communications·2026
Same author

ACSS2-mediated metabolic-epigenetic crosstalk drives Fulvestrant resistance and represents a novel therapeutic target.

NPJ breast cancer·2026
Same author

[Advances in synthesis regulation, extraction technology, and pharmacological application of <i>Gelsemium elegans</i> alkaloids].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026
Same author

Intolerance of uncertainty and symptom-level associations between generalized anxiety and depression in adolescence: A large-scale subgroup network analysis.

Comprehensive psychiatry·2026
Same author

Cadonilimab in the treatment of advanced metastatic soft tissue clear cell sarcoma achieved complete remission: a case report.

Frontiers in oncology·2026
Same author

Bone remodeling: a central mechanism in prostate cancer bone metastasis.

PeerJ·2026

Related Experiment Video

Updated: Feb 22, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

13.0K

27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator.

Sisi He1, Erik R Nelson2

  • 1Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Maturitas
|September 20, 2017
PubMed
Summary
This summary is machine-generated.

Cholesterol metabolite 27-hydroxycholesterol (27HC) acts as an endogenous selective estrogen receptor modulator (SERM). 27HC influences various diseases, potentially mediating cholesterol

Keywords:
27-hydroxycholesterolCholesterolEstrogenEstrogen receptorSelective estrogen receptor modulator

More Related Videos

Screening for Phytoestrogens using a Cell-based Estrogen Receptor &#946; Reporter Assay
06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

5.4K
Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

6.8K

Related Experiment Videos

Last Updated: Feb 22, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

13.0K
Screening for Phytoestrogens using a Cell-based Estrogen Receptor &#946; Reporter Assay
06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

5.4K
Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

6.8K

Area of Science:

  • Endocrinology and Metabolism
  • Molecular Pharmacology
  • Oncology

Background:

  • Estrogen receptors (ERs) regulate critical physiological and pathophysiological processes, including reproduction, bone and cardiovascular health, and breast cancer.
  • Selective estrogen receptor modulators (SERMs) exhibit tissue- and context-specific responses, exemplified by tamoxifen.
  • The cholesterol metabolite 27-hydroxycholesterol (27HC) has emerged as an endogenous SERM.

Purpose of the Study:

  • To provide an overview of ER pharmacology.
  • To summarize current research implicating 27HC in diverse diseases.
  • To highlight clinical data supporting 27HC's role in disease pathogenesis.

Main Methods:

  • Literature review of ER pharmacology.
  • Synthesis of existing research on 27HC's biological activities.
  • Analysis of clinical data related to 27HC and disease.

Main Results:

  • 27HC demonstrates SERM-like activities in conditions such as atherosclerosis, osteoporosis, breast and prostate cancers, and neurodegenerative diseases.
  • 27HC concentrations correlate with cholesterol levels, suggesting it may mediate some of cholesterol's biological effects.
  • Clinical evidence supports 27HC's involvement in the discussed disease states.

Conclusions:

  • 27HC is a significant endogenous SERM with broad implications across multiple disease areas.
  • Understanding 27HC's role is crucial for developing novel therapeutic strategies targeting estrogen receptor pathways.
  • Further research, particularly clinical studies, is warranted to fully elucidate 27HC's impact on human health and disease.