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Signals that drive T-bet expression in B cells

Arpita Myles1, Patricia J Gearhart2, Michael P Cancro1

  • 1Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.

Cellular Immunology
|September 20, 2017
PubMed

Transcription factors regulate various developmental and functional aspects of B cells. T-bet is a recently appreciated transcription factor associated with "Age-associated B cells" or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by interplay between various cytokines, notably, the TFH cytokines IL-21, IL-4 and IFNγ. Adaptive signals by themselves cannot upregulate T-bet; however, they have a synergistic effect on induction of T-bet by innate receptors. The functional role of T-bet+ B cells is unclear, although it is known that T-bet promotes class switching to IgG2a/c. It is likely T-bet serves dichotomous roles in B cells, promoting pathogenic autoreactive antibodies on one hand but mediating microbial immunity on the other, making it a target of interest in both therapeutic and prophylactic settings.

Keywords:
B cellIFN-gammaIL21SignallingT-betTLR

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