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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
Published on: October 17, 2025
Needs and opportunities in bio-design automation: four areas for focus
Evan Appleton1, Douglas Densmore2, Curtis Madsen2
1Harvard Medical School, Department of Genetics, Harvard University, Boston 02115, USA; Wyss Institute for Biologically Inspired Design, Harvard University, Boston 02115, USA.
Abstract:
Bio-design automation (BDA) is an emerging field focused on computer-aided design, engineering principles, and automated manufacturing of biological systems. Here we discuss some outstanding challenges for bio-design that can be addressed by developing new tools for combinatorial engineering, equipment interfacing, next-generation sequencing, and workflow integration. These four areas, while not an exhaustive list of those that need to be addressed, could yield advances in bio-design, laboratory automation, and biometrology.
