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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Altered functional connectivity in mesial temporal lobe epilepsy.

Hana Burianová1, Nahla L Faizo2, Marcus Gray2

  • 1Department of Psychology, Swansea University, Swansea, United Kingdom, United Kingdom; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.

Epilepsy Research
|September 20, 2017
PubMed
Summary

Mesial temporal lobe epilepsy (mTLE) disrupts resting state networks, impacting brain connectivity before interictal spikes. These changes may explain cognitive issues in epilepsy patients.

Keywords:
Default-mode networkDorsal attentional networkFunctional connectivityMesial temporal lobe epilepsySalience network

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Area of Science:

  • Neuroscience
  • Epileptology
  • Functional Neuroimaging

Background:

  • Mesial temporal lobe epilepsy (mTLE) is increasingly linked to altered functional connectivity beyond the hippocampus.
  • Resting state networks (RSNs) like the default mode network (DMN), salience network (SN), and dorsal attentional network (DAN) are crucial for cognition.
  • The impact of epileptiform activity on these RSNs remains poorly understood.

Purpose of the Study:

  • To investigate functional connectivity alterations in the DMN, SN, and DAN in mTLE patients versus healthy controls.
  • To examine how functional connectivity changes in relation to interictal spikes and the pre-spike period.
  • To utilize simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) for precise temporal analysis.

Main Methods:

  • Simultaneous EEG-fMRI was employed to record brain activity in mTLE patients and healthy controls.
  • Functional connectivity was analyzed within the DMN, SN, and DAN during resting state.
  • Connectivity patterns were compared between groups and examined in the context of interictal spike onset.

Main Results:

  • mTLE patients exhibited widespread alterations in DMN, SN, and DAN functional connectivity compared to controls.
  • These alterations included reduced connectivity to prefrontal regions and increased connectivity to subcortical/posterior areas.
  • Crucially, a pre-interictal spike state in mTLE showed decreased DMN connectivity and reduced SN/DAN synchronization.

Conclusions:

  • mTLE significantly alters resting-state functional connectivity across key brain networks.
  • Pre-epileptiform activity is associated with specific network disruptions, potentially contributing to spike generation.
  • These findings highlight network dysregulation in mTLE and its potential role in cognitive deficits associated with epilepsy.