Study on the excision and integration mediated by class 1 integron in Streptococcus pneumoniae
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Updated: Feb 22, 2026

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes
Published on: June 19, 2015
Qun Lin1, Pusheng Xu2, Jiaowu Li1
1Department of Respiratory, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan 528315, China.
Abstract:
As a novel antibiotic resistance mobile element, integron was recognized as a primary source of antibiotic genes among Gram-positive organisms for its excision and integration of exogenous genes. In this study, Streptococcus pneumoniae was subjected to investigate the excision and integration of class 1 integron with eight different plasmids. As the results indicated, excision in both att site and gene cassettes were successfully observed, which was further confirmed by integration assays and PCR amplification. The observation of class 1 integron mediated excision and integration of various exogenous antibiotics resistance genes may raise the attention of integrons as novel antibiotic resistance determinant in Gram-positive bacteria, especially in Streptococcus.
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