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Postdonation Anemia in Living Kidney Donors
S Shah1, B Lankowsky2, T Gao3
1Division of Nephrology, University of Cincinnati, Cincinnati, Ohio.
Transplantation Proceedings
|September 20, 2017
Summary
Postdonation anemia (PDA) affects 11.8% of living kidney donors (LKDs). Lower kidney volume and predonation hemoglobin levels are key factors influencing PDA development after nephrectomy.
Area of Science:
- Nephrology
- Transplantation Immunology
- Hematology
Background:
- The impact of nephrectomy on anemia in living kidney donors is under-researched.
- Predonation anemia and remaining kidney volume are hypothesized to influence postdonation anemia (PDA).
Purpose of the Study:
- To investigate the determinants of hemoglobin concentration and PDA in living kidney donors.
- To identify factors associated with postdonation anemia.
Main Methods:
- A cohort of 398 living kidney donors (LKDs) from 2001-2013 was analyzed.
- Demographic, hematologic, renal mass (kidney volume via CT scans), and renal function data were collected.
- Univariate and multivariable logistic regression analyses were used to identify factors associated with PDA.
Main Results:
- The prevalence of PDA was 11.8% at a median follow-up of 601 days.
- Lower kidney volume (326 ± 52 mL vs 368 ± 70 mL) was observed in donors with PDA.
- Multivariable analysis identified total kidney volume and predonation anemia as independent predictors of PDA.
Conclusions:
- Postdonation anemia is a prevalent complication following living kidney donation.
- Donor kidney volume and predonation hemoglobin levels are significant determinants of PDA.
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