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Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Functional polymer-based siRNA delivery carrier that recognizes site-specific biosignals.

Hiroyasu Takemoto¹, Nobuhiro Nishiyama²

¹Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|September 20, 2017

Summary

Smart polymers respond to biological signals for targeted delivery of small interfering RNA (siRNA) carriers. This enables precise gene silencing by triggering programs within cells.

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Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

Area of Science:

Biomaterials science
Polymer chemistry
Molecular biology

Background:

Functional polymers can be designed for site-specific applications.
Responsive polymers can interact with specific biological signals.
Small interfering RNA (siRNA) delivery requires targeted strategies for effective gene silencing.

Purpose of the Study:

To review rational design strategies for functional polymers responsive to biosignals.
To present examples of smart carriers for siRNA delivery.
To highlight the potential of these systems for targeted gene silencing.

Main Methods:

Literature review of responsive polymer design.
Analysis of polymer-biosignal interactions.
Case studies of siRNA delivery systems.

Main Results:

Functional polymers can be engineered to respond to specific microenvironmental cues.
Sequential biosignal triggering enables sophisticated delivery programs.
Smart carriers facilitate targeted siRNA delivery to the cytosol for gene silencing.

Conclusions:

Responsive polymers offer promising platforms for advanced siRNA delivery systems.
Tailored polymer design is crucial for achieving site-specific and triggered functionalities.
These smart carriers hold potential for effective and targeted gene silencing applications.