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Safety perspectives on parenteral H2-receptor antagonists
1Department of Medicine, University of Connecticut Health Center, Farmington 06032.
The American Journal of Medicine
|December 18, 1987
Summary
Histamine (H2)-receptor antagonists generally have excellent safety records. While minor differences exist, their safety profiles are largely similar, especially regarding central nervous system effects and drug interactions.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Histamine (H2)-receptor antagonists are widely used.
- Controversy exists regarding their comparative safety profiles.
Purpose of the Study:
- To analyze safety issues of H2-receptor antagonists.
- To provide perspective on identified safety concerns, including parenteral use.
Main Methods:
- Review of extensive safety literature on H2-receptor antagonists.
- Focus on central nervous system effects and drug interactions.
Main Results:
- H2-receptor antagonists, as a class, demonstrate favorable safety records.
- Analysis revealed some minor differences in individual agent safety profiles.
Conclusions:
- The overall safety profiles of H2-receptor antagonists are remarkably similar.
- The class is considered safe, with few significant distinctions in safety.