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Predictors of Microbiologically Confirmed Intrathoracic Tuberculosis

Rakhi Jain1, Aparna Mukherjee1, Mohit Singla1

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.

Indian Journal of Pediatrics
|September 20, 2017
PubMed

Insights

Low body mass index and higher monocyte to lymphocyte ratios are key indicators for confirming intrathoracic tuberculosis in children. These factors aid in diagnosing pediatric tuberculosis, especially in challenging cases.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Intrathoracic tuberculosis (TB) in children presents diagnostic challenges.
  • Microbiological confirmation is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To identify risk factors associated with microbiologically confirmed intrathoracic tuberculosis in pediatric patients.
  • To improve diagnostic accuracy for childhood TB.

Main Methods:

  • A study involving children aged 6 months to 15 years with suspected intrathoracic TB.
  • Microbiological confirmation utilized smear microscopy, Xpert MTB/RIF, and MGIT culture.
  • Univariate and multivariate analyses assessed associations between various factors and microbiological confirmation.

Main Results:

  • Microbiological confirmation was achieved in 25% of enrolled children.
  • Factors associated with confirmation included female gender, older age, parenchymal lesions, low BMI, cough, weight loss, lower hemoglobin, and higher monocyte:lymphocyte ratio.
  • BCG vaccination was less common in microbiologically confirmed cases.
  • Multivariate analysis identified low BMI for age and high monocyte:lymphocyte ratio as significant predictors.

Conclusions:

  • Low body mass index for age is a significant risk factor for microbiologically confirmed intrathoracic tuberculosis in children.
  • An elevated monocyte to lymphocyte ratio is also associated with microbiological confirmation of pediatric TB.
  • These findings can aid in the early identification and diagnosis of TB in children.
Abstract

Keywords:
Childhood tuberculosisIntrathoracic tuberculosisMGIT culturePredictors

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