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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

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Atypical E2Fs inhibit tumor angiogenesis.

B G M W Weijts1,2, B Westendorp1, B T Hien1

  • 1Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Oncogene
|September 20, 2017
PubMed
Summary

Atypical E2F transcription factors (E2F7 and E2F8) suppress tumor angiogenesis, a key cancer hallmark. This contrasts with their role in fetal development, revealing a novel tumor suppressor mechanism involving DLL4 regulation.

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