Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Energy Balance01:19

Energy Balance

1.3K
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
1.3K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

312
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
312
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

303
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
303

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between early weight gain and later adiposity in Sri Lankan adolescents.

Journal of developmental origins of health and disease·2020
Same author

How much exercise should be promoted to raise total daily energy expenditure and improve health?

Obesity reviews : an official journal of the International Association for the Study of Obesity·2018
Same author

Rationale for novel intermittent dieting strategies to attenuate adaptive responses to energy restriction.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2018
Same author

Experiences of using very low energy diets for weight loss by people with overweight or obesity: a review of qualitative research.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2018
Same author

Study protocol: a randomised controlled trial of supervised resistance training versus aerobic training in Sri Lankan adults with type 2 diabetes mellitus: SL-DART study.

BMC public health·2018
Same author

Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity.

International journal of obesity (2005)·2017

Related Experiment Video

Updated: Feb 22, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

9.6K

Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study.

N M Byrne1,2, A Sainsbury3, N A King2

  • 1School of Health Sciences, Faculty of Health, University of Tasmania, Launceston, Tasmania, Australia.

International Journal of Obesity (2005)
|September 20, 2017
PubMed
Summary

Intermittent energy restriction (ER) led to greater weight and fat loss compared to continuous ER. This approach may improve weight loss efficiency by reducing metabolic compensation.

More Related Videos

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

1.4K
Infrared Thermography for the Detection of Changes in Brown Adipose Tissue Activity
08:16

Infrared Thermography for the Detection of Changes in Brown Adipose Tissue Activity

Published on: September 28, 2022

2.9K

Related Experiment Videos

Last Updated: Feb 22, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

9.6K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

1.4K
Infrared Thermography for the Detection of Changes in Brown Adipose Tissue Activity
08:16

Infrared Thermography for the Detection of Changes in Brown Adipose Tissue Activity

Published on: September 28, 2022

2.9K

Area of Science:

  • Metabolism and Obesity Research
  • Nutritional Science
  • Human Physiology

Background:

  • Obesity is a complex metabolic disorder associated with significant health risks.
  • Continuous energy restriction (ER) can lead to compensatory metabolic slowdown, potentially hindering long-term weight management.
  • The MATADOR study investigated alternative ER strategies to optimize weight loss outcomes.

Purpose of the Study:

  • To compare the effectiveness of intermittent ER versus continuous ER on weight loss efficiency.
  • To determine if intermittent ER attenuates the compensatory metabolic responses typically seen with continuous ER.
  • To assess the impact of intermittent ER on body composition and resting energy expenditure.

Main Methods:

  • Fifty-one men with obesity were randomized into continuous ER (CON) or intermittent ER (INT) groups for 30 weeks.
  • Intermittent ER involved alternating 2-week blocks of ER with 2-week blocks of energy balance.
  • Body weight, fat mass, fat-free mass, and resting energy expenditure were measured throughout the intervention.

Main Results:

  • Intermittent ER resulted in significantly greater weight loss (14.1 kg) and fat mass loss (12.3 kg) compared to continuous ER (9.1 kg and 8.0 kg, respectively).
  • Fat-free mass loss was similar between groups.
  • While absolute resting energy expenditure reduction did not differ, it was significantly lower in the intermittent ER group after adjusting for body composition changes.

Conclusions:

  • Intermittent energy restriction is more effective for weight loss and fat loss than continuous energy restriction in men with obesity.
  • Incorporating energy balance periods within an ER regimen may mitigate adaptive thermogenesis, enhancing overall weight loss efficiency.
  • Intermittent ER represents a promising strategy for managing obesity and improving metabolic health.