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Laminin associated with BMP7 as potential secondary astrocytic glioma fiber differentiation targets
1Departments of Neurosurgery, Chinese People's Armed Police Force General Hospital, Haidian District, Beijing, China. gengsheng_mao1@163.com.
Objective:
To investigate the activation of the BMP7 and laminin pathway is associated with glioma cell proliferation and differentiation.
Patients And Methods:
We enrolled 65 patients with primary operable glioma. Laminin and BMP7 protein expression and its subcellular localization were studied by immunofluorescence.
Results:
We detected a higher level of BMP7 expression in glioma tissue in patients with a lower grade of glioma who had a lower eosinophil count. Compared to patients with a higher grade of glioma, we observed a lower level of laminin expression in patients with a lower grade of glioma.
Conclusions:
Our data indicated a potential link between eosinophil counts and the expression levels of laminin and BMP7 in glioma differentiation.
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