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Regulation of Clusterin Gene Expression
Marilina Garcia-Aranda1, Alfonso Serrano2, Maximino Redondo1
1Department of Biochemistry, REDISSEC, Hospital Costa del Sol, Carretera de Cadiz km, 187, 29600 Marbella. Malaga, Spain.
Current Protein & Peptide Science
|September 20, 2017
Summary
Clusterin, a protein with diverse cellular roles, is linked to diseases like cancer and Alzheimer's. Understanding its complex expression may unlock new therapeutic strategies for various pathologies.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- Clusterin is a multifunctional glycoprotein implicated in various cellular processes.
- Deregulation of clusterin expression is associated with pathologies such as cancer and Alzheimer's disease.
- Clusterin exhibits a dichotomous role, contributing to contradictory findings in research.
Purpose of the Study:
- To review factors affecting clusterin expression.
- To evaluate clusterin as a potential therapeutic target.
- To explore new treatment strategies for cancer and other diseases based on clusterin.
Main Methods:
- Literature review of studies on clusterin expression.
- Analysis of clusterin's role in cellular processes (apoptosis, cell cycle, DNA repair, therapy resistance).
- Evaluation of clusterin isoforms and their impact.
Main Results:
- Clusterin is involved in apoptosis, cell cycle regulation, DNA repair, and therapy resistance.
- Multiple RNA transcripts and protein isoforms complicate the understanding of clusterin.
- Contradictory findings stem from the dichotomous role of clusterin isoforms.
Conclusions:
- Understanding clusterin's complex gene/protein interactions is crucial.
- Targeting clusterin may offer new therapeutic avenues for cancer and other diseases.
- Further research into clusterin expression factors is warranted.
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