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Susceptibility of Bordetella pertussis to five quinolone antimicrobic drugs

M E Appleman1, T L Hadfield, J K Gaines

  • 1Department of Infectious Diseases, Wilford Hall USAF Medical Center, Lackland AFB, Texas 78236.

Diagnostic Microbiology and Infectious Disease
|October 1, 1987
PubMed

Insights

Ciprofloxacin showed the best in vitro activity against Bordetella pertussis, with other quinolones also demonstrating significant antimicrobial effects. This research aids in understanding effective treatments for pertussis.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Bordetella pertussis causes whooping cough, a significant public health concern.
  • Antimicrobial resistance necessitates ongoing evaluation of treatment options.
  • Quinolone antimicrobics are a class of drugs used to treat bacterial infections.

Purpose of the Study:

  • To evaluate the in vitro activity of five quinolone antimicrobic agents against clinical strains of Bordetella pertussis.
  • To determine the minimum inhibitory concentration (MIC) for each agent.
  • To identify the most effective quinolone for potential pertussis treatment.

Main Methods:

  • Agar dilution method was employed.
  • Seventeen clinical strains of Bordetella pertussis were tested.
  • Five quinolone antimicrobic agents were assessed for their MIC90 values.

Main Results:

  • Ciprofloxacin exhibited the highest in vitro activity with an MIC90 of 0.06 microgram/ml.
  • Norfloxacin, ofloxacin, and enoxacin showed high activity with MIC90s of 0.25, 0.25, and 0.5 microgram/ml, respectively.
  • Cinoxacin demonstrated moderate activity with an MIC90 of 4.0 microgram/ml.

Conclusions:

  • Ciprofloxacin is the most potent quinolone against the tested Bordetella pertussis strains in vitro.
  • Norfloxacin, ofloxacin, and enoxacin are also effective options.
  • Further clinical studies are warranted to confirm in vitro findings.

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