Fourier-Transform MS and Closed-Path Multireflection Time-of-Flight MS Using an Electrostatic Linear Ion Trap

Area of Science:

• Analytical Chemistry
• Mass Spectrometry Instrumentation

Background:

• Electrostatic linear ion traps (ELITs) are versatile tools for ion manipulation and analysis.
• Simultaneous acquisition of mass spectra using different techniques can enhance analytical capabilities.

Purpose of the Study:

• To configure an ELIT for simultaneous Fourier transform mass spectrometry (FT-ELIT MS) and multireflection time-of-flight mass spectrometry (MR-TOF MS).
• To evaluate the complementarity and specific advantages of each technique within the ELIT framework.

Main Methods:

• Simultaneous data acquisition using FT-ELIT MS (frequency domain) and MR-TOF MS (time domain) within a single ELIT setup.
• Utilizing image charge detection for FT-ELIT MS and ion flight time measurement for MR-TOF MS.
• Comparing resolution, mass-to-charge ratio (m/z) range, and peak capacity of both methods.

Main Results:

• The ELIT successfully enabled simultaneous FT-ELIT MS and MR-TOF MS data acquisition due to independent detection schemes.
• MR-TOF MS offers faster resolution increase with time but is limited in m/z range and peak capacity.
• FT-ELIT MS is suitable for wide m/z range applications, while MR-TOF MS excels in high-resolution "zoom-in" modes.

Conclusions:

• The developed ELIT provides a dual-mode mass spectrometry platform combining FT-ELIT MS and MR-TOF MS.
• The complementary nature of these techniques allows for tailored analytical strategies based on specific experimental requirements.
• This dual-mode ELIT enhances analytical flexibility for diverse mass spectrometry applications.