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Related Experiment Video

Updated: Feb 22, 2026

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Epigenetics and Precision Oncology.

Rachael J Werner¹, Andrew D Kelly, Jean-Pierre J Issa

¹From the *Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Cancer Journal (Sudbury, Mass.)

|September 20, 2017

Summary

This summary is machine-generated.

Epigenetic alterations, particularly DNA methylation defects, are hallmarks of cancer development and recurrence. These epigenetic marks offer new avenues for cancer diagnosis, prognosis, and personalized treatment strategies.

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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Published on: April 5, 2018

Area of Science:

Oncology
Epigenetics
Cancer Biology

Background:

Epigenetic alterations, including DNA methylation defects and histone modifications, are prevalent across all cancer types.
These changes are detectable throughout tumor formation, from early onset to metastasis and recurrence.
Epigenetic marks are increasingly relevant for identifying at-risk populations, refining diagnostics, and guiding treatment decisions.

Purpose of the Study:

To review epigenetic precision medicine, focusing on aberrant DNA methylation.
To highlight the clinical utility and therapeutic potential of targeting epigenetic modifications.
To discuss the future directions of epigenetic-based cancer therapies.

Main Methods:

Review of current literature on epigenetic alterations in cancer.
Analysis of well-supported examples of epigenetic precision medicine.
Focus on DNA methylation as a key epigenetic mechanism.

Main Results:

Epigenetic modifications are integral to cancer progression and can serve as biomarkers.
Targeting epigenetic alterations offers novel therapeutic opportunities for personalized medicine.
DNA methylation is particularly valuable due to its stability and ease of detection.

Conclusions:

Epigenetic precision medicine holds significant promise for transforming cancer care.
Aberrant DNA methylation is a key focus for developing new diagnostic and therapeutic strategies.
Further research into epigenetic modifications will drive advancements in personalized oncology.