Proposed anti-HSV compounds isolated from Simira species
Jessica F Cavalcanti1, Marcelo F de Araujo2, Priscila B Gonçalves3
1a Laboratorio Experimental de Drogas Citotóxicas e Antivirais, Departamento de Virologia , Instituto de Microbiologia Paulo Góes, Universidade Federal do Rio de Janeiro (UFRJ) , Rio de Janeiro , Brazil.
Abstract:
Secondary metabolites isolated from Simira eleiezeriana and Simira glaziovii were evaluated against herpes simplex virus (HSV-1) and (HSV-2). The 50% effective concentrations values (EC50) were calculated from the dose-response curve and the selectivity index (SI) against the virus. The physicochemical data LogP, (PSA), (NRB), (HBA) and (HBD) were obtained using Marvin Sketch. Among the tested compounds, conipheraldeyde, harman and simirane A showed better results with EC50 6.39; 4.90; 4.61 µg/mL and SI 78.3; 11.8; 7.01, respectively, for HSV-1, and EC50 41.2; 71.8; 3.73 µg/mL and SI 12.1; 24.7; 8.7, respectively, for HSV-2. The percentage of inhibition (PI) obtained for HSV-1 were higher than 60%, and for HSV-2 these compounds showed PI > 90%. The physical chemical data showed that the most active compounds satisfy the attributes for drugs with good oral bioavailability.
