Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

27.6K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
27.6K
Telomeres and Telomerase02:41

Telomeres and Telomerase

7.5K
7.5K
Chromosome Structure02:40

Chromosome Structure

26.8K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
26.8K
Replication in Eukaryotes01:29

Replication in Eukaryotes

18.0K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
18.0K
Replication in Eukaryotes02:31

Replication in Eukaryotes

206.2K
Overview
206.2K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

19.6K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
19.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Context-dependent telomere dynamics in wild fish populations under anthropogenic stress.

Environmental science and pollution research international·2026
Same author

The antineoplastic agent streptozotocin induces short-term telomere instability in Epstein-Barr virus-transformed human lymphoblastoid cells.

Experimental cell research·2026
Same author

Bleomycin induces short-term telomere fragility in Epstein-Barr virus-transformed human lymphoblastoid cells.

Mutation research. Genetic toxicology and environmental mutagenesis·2025
Same author

Age and growth patterns of the ten spotted live-bearing fish (Cnesterodon decemmaculatus) along a polluted freshwater system.

Journal of fish biology·2024
Same author

Bleomycin-induced chromosomal aberrations in Epstein-Barr virus-transformed human lymphoblastoid cells.

Mutation research. Genetic toxicology and environmental mutagenesis·2024
Same author

Considerations on the scoring of telomere aberrations in vertebrate cells detected by telomere or telomere plus centromere PNA-FISH.

Mutation research. Reviews in mutation research·2024

Related Experiment Video

Updated: Feb 22, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K

Interstitial telomeric sequences in vertebrate chromosomes: Origin, function, instability and evolution.

Alejandro D Bolzán1

  • 1Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biología Celular (IMBICE, CICPBA-UNLP-CONICET La Plata), C.C. 403, 1900 La Plata, Argentina; Facultad de Ciencias Naturales y Museo, UNLP, Calle 60 y 122, 1900 La Plata, Argentina.

Mutation Research. Reviews in Mutation Research
|September 21, 2017
PubMed
Summary
This summary is machine-generated.

Interstitial telomeric sequences (ITSs) are telomere-like repeats found in non-terminal chromosome regions of vertebrates. This review explores their origin, function, instability, and evolution, highlighting their role in genome evolution.

Keywords:
Chromosomal aberrationsChromosome instabilityGenome instabilityInterstitial telomeric repeatsKaryotypic evolutionTelomere

More Related Videos

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

1.3K
In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

12.1K

Related Experiment Videos

Last Updated: Feb 22, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K
Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

1.3K
In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

12.1K

Area of Science:

  • Genetics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Telomeres, protective caps at chromosome ends, consist of repetitive sequences.
  • Interstitial telomeric sequences (ITSs) are telomere-like repeats found in non-terminal chromosomal regions across vertebrates.
  • ITSs are classified into four types: short, subtelomeric, fusion, and heterochromatic, with varying prevalence in species like humans.

Purpose of the Study:

  • To review the current understanding of interstitial telomeric sequences (ITSs) in vertebrate chromosomes.
  • To summarize the origin, function, instability, and evolutionary significance of ITSs.
  • To provide a comprehensive overview of ITSs classification and distribution.

Main Methods:

  • Literature review and synthesis of existing research on ITSs.
  • Analysis of sequence organization, localization, and flanking sequences of ITSs.
  • Comparative genomics to understand ITSs distribution and evolution across vertebrate species.

Main Results:

  • ITSs are found in various locations within chromosomes, including pericentromeric and centromeric regions.
  • Four distinct types of ITSs (short, subtelomeric, fusion, heterochromatic) exhibit different characteristics and distributions.
  • Heterochromatic ITSs are prevalent in vertebrates but absent in humans, while the other types are found in the human genome.

Conclusions:

  • Interstitial telomeric sequences (ITSs) are significant elements in vertebrate genome evolution and instability.
  • Understanding ITSs provides insights into chromosomal rearrangements and genome dynamics.
  • Further research into ITSs can elucidate mechanisms of genome evolution and stability across species.