Roles for Innate Immunity in Combination Immunotherapies
Kelly D Moynihan1,2,3, Darrell J Irvine4,2,3,5,6
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Cancer Research
|September 21, 2017
Summary
Harnessing innate immunity alongside adaptive immunity offers a promising strategy for developing novel cancer immunotherapies. Combining these approaches may lead to more effective eradication of established tumors.
Area of Science:
- Immunology
- Oncology
- Cancer Research
Background:
- Immunity involves coordinated innate and adaptive immune cell responses.
- Current cancer immunotherapies primarily focus on adaptive immunity.
- There's a growing recognition of innate immunity's role in antitumor responses.
Purpose of the Study:
- To review the antitumor activities of innate immune cells.
- To explore the synergistic mechanisms between innate and adaptive immunity against tumors.
- To discuss combination therapies that recruit both arms of the immune system for tumor eradication.
Main Methods:
- Literature review of antitumor activities of innate immune cells.
- Analysis of mechanisms of synergy between innate and adaptive immune responses.
- Discussion of recent studies on combination immunotherapies.
Main Results:
- Innate immune cells possess significant antitumor activities.
- Synergy exists between innate and adaptive immunity in controlling tumors.
- Combination therapies leveraging both innate and adaptive immunity show potential for eradicating established tumors.
Conclusions:
- Integrated immune responses involving both innate and adaptive immunity are crucial for effective cancer treatment.
- Novel therapeutic strategies should aim to elicit a combined immune response against cancer.
- Combination immunotherapies represent a promising frontier in cancer treatment.
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