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Updated: Feb 22, 2026
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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
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Immune Cell Population in Ovarian Tumor Microenvironment
Dong Li Cai1,2, Li-Ping Jin1,2
1Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Journal of Cancer
|September 21, 2017
Summary
Ovarian cancer research highlights the complex tumor immune microenvironment. Understanding immune cell interactions is key to developing effective immunotherapies for this gynecological malignancy.
Area of Science:
- Oncology
- Immunology
- Gynecologic Oncology
Background:
- Ovarian cancer is a leading cause of cancer death among gynecological malignancies in China.
- Its unique tumor immune microenvironment significantly influences disease progression.
- Immune cell infiltration within tumors can correlate with antitumor activity.
Purpose of the Study:
- To review the primary immune cell populations within the ovarian tumor microenvironment.
- To discuss the roles of these immune cells in ovarian cancer progression.
- To provide insights for identifying novel therapeutic targets.
Main Methods:
- Literature review focusing on immune cell populations in ovarian cancer.
- Analysis of existing data on immune cell infiltration and function.
- Synthesis of current knowledge on immune cell interactions within the tumor microenvironment.
Main Results:
- Immune cell populations exhibit diverse roles, both promoting and inhibiting antitumor responses.
- An imbalance between immune activation and suppression is linked to oncogenesis.
- Understanding these complex interactions is crucial for therapeutic development.
Conclusions:
- Further investigation into the ovarian tumor immune microenvironment is essential.
- Targeting specific immune cell interactions may lead to more effective immunotherapies.
- This review offers a new perspective for identifying promising therapeutic targets in ovarian cancer.
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