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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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Histone Variants at the Centromere02:30

Histone Variants at the Centromere

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Heterochromatin02:38

Heterochromatin

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
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Heterochromatin02:38

Heterochromatin

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Related Experiment Video

Updated: Feb 22, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
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Expression Analysis of Mammalian Linker-histone Subtypes

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Common Expression Quantitative Trait Loci Shared by Histone Genes.

Hanseol Kim1, Yujin Suh1, Chaeyoung Lee1

  • 1Department of Bioinformatics and Life Science, Soongsil University, Seoul, Republic of Korea.

International Journal of Genomics
|September 21, 2017
PubMed
Summary
This summary is machine-generated.

This study identified 31 expression quantitative trait loci (eQTLs) for 29 histone genes in European lymphoblastoid cell lines. Twelve eQTLs regulate multiple histone genes, impacting cell cycle transcription.

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Area of Science:

  • Genetics
  • Molecular Biology
  • Bioinformatics

Background:

  • Histone genes are crucial for DNA packaging and gene regulation.
  • Understanding the genetic regulation of histone gene expression is vital for comprehending cellular processes.
  • Expression quantitative trait loci (eQTLs) help map genetic variants influencing gene expression.

Purpose of the Study:

  • To identify expression quantitative trait loci (eQTLs) for histone genes using genome-wide association studies (GWAS).
  • To investigate common eQTLs associated with multiple histone genes.
  • To explore the association of identified eQTLs with other genes.

Main Methods:

  • Genome-wide association study (GWAS) on 373 European lymphoblastoid cell lines (LCLs).
  • Linear regression model to identify single-nucleotide polymorphisms (SNPs) associated with histone gene expression.
  • Linkage disequilibrium analysis to determine the number of eQTLs.
  • Transcriptome-wide association analysis to examine associations with additional genes.

Main Results:

  • Identified 31 eQTLs for 29 histone genes (P < 2.97 × 10^-10).
  • Found 12 eQTLs associated with the expression of multiple histone genes.
  • Discovered associations between identified eQTLs and 80 additional genes (P < 4.75 × 10^-6), notably RPPH1, SCARNA2, and SCARNA7.

Conclusions:

  • Shared eQTLs suggest a coordinated regulation of histone and other genes, potentially during the cell cycle.
  • The findings provide insights into the genetic architecture influencing histone gene expression.
  • Further research is warranted to fully elucidate the transcriptional regulatory mechanisms involved.