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Monitoring Leiomyoma Response to Uterine Artery Embolization Using Diffusion and Perfusion Indices from
Mengqiu Cao1, Lijun Qian1, Xuebin Zhang2
1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Purpose:
To investigate the potential of diffusion and perfusion indices (ADC and perfusion fraction f) from DWI at 3.0 T in monitoring treatment response to uterine artery embolization (UAE) at 6-month follow-up.
Methods:
Twelve female patients with uterine fibroids who underwent 3.0-T pelvic DWI before and 6 months after UAE were included. ADC and perfusion fraction f were calculated from DWI. The Wilcoxon signed-rank test and Spearman rank correlation test were used for statistics.
Results:
Seventeen fibroids were studied. The median ADCs showed a significant increase from 1.20 × 10-3 mm2/s (range, 0.86-1.66 × 10-3 mm2/s) at baseline to 1.56 × 10-3 mm2/s (range, 1.00-1.86 × 10-3 mm2/s) at 6-month follow-up (P = 0.0003). Conversely, the median perfusion fraction f was significantly decreased after UAE (P = 0.0001), with a median pre-UAE value of 14.2% (range, 6.7%-17.6%) and a median post-UAE value of 9.2% (range, 3.2%-14.6%). Significant correlations were found between fibroid volume reduction rate and percentage changes in ADC and perfusion fraction f at 6-month follow-up relative to baseline, with ρ values of -0.50 (P = 0.04) and 0.55 (P = 0.02), respectively.
Conclusion:
ADC and perfusion fraction f obtained from DWI at 3.0 T may help to evaluate treatment response to UAE.
