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Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes

Filipe M Cunha1, Joana Pereira2, Pedro Marques2

  • 1Serviço de Endocrinologia do Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.

Journal of Diabetes Research
|September 21, 2017
PubMed

Insights

In acute heart failure (HF), diabetes did not significantly alter B-type natriuretic peptide (BNP) levels or one-year mortality in matched patients. This suggests similar neurohumoral activation between diabetic and nondiabetic HF individuals.

Area of Science:

  • Cardiology
  • Endocrinology
  • Clinical Research

Background:

  • Elevated B-type natriuretic peptide (BNP) is a key indicator in heart failure (HF).
  • Diabetic patients with chronic HF often exhibit higher BNP levels compared to nondiabetics.
  • This study investigates BNP differences in acute HF between diabetic and nondiabetic populations.

Purpose of the Study:

  • To compare B-type natriuretic peptide (BNP) levels in patients with acute heart failure (HF) who have diabetes versus those without.
  • To assess the prognostic impact of diabetes on one-year mortality in acute HF patients.

Main Methods:

  • A convenience sample of acute HF patients was selected from a prospective cohort.
  • Pair-matched analysis was performed, matching diabetic patients with nondiabetic patients based on age, gender, and left ventricular systolic dysfunction.
  • Cox-regression analysis was utilized to evaluate the prognostic significance of diabetes.

Main Results:

  • The study included 328 patients (mean age 78 years, 44.5% male). Diabetic patients had higher rates of hypertension, ischemic HF, higher BMI, lower hemoglobin, and poorer renal function.
  • Despite these differences, neither admission nor discharge BNP values differed between diabetic and matched nondiabetic patients.
  • One-year mortality was similar between the groups (26.8% in diabetics vs. 28.0% in nondiabetics), with a hazard ratio of 1.00 for diabetics.

Conclusions:

  • Heart failure patients with diabetes demonstrate comparable neurohumoral activation to their nondiabetic counterparts.
  • After matching for key demographic and clinical factors, one-year mortality rates are not significantly different between diabetic and nondiabetic acute HF patients.
Abstract

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