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Updated: Feb 22, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
[Pathogenesis and genetics of osteosarcoma : Current concepts and developments]
1Knochentumor-Referenzzentrum am Institut für Pathologie, Universitätsspital Basel, Universität Basel, Basel, Schweiz. daniel.baumhoer@usb.ch.
Abstract:
Osteosarcomas are genetically complex tumours for which the cell of origin and the molecular pathogenesis are still poorly understood. Despite intensive multimodal treatment protocols only two thirds of patients currently survive the disease which is at least partly due to the early occurring chromosomal instability resulting in marked inter- and intratumoral heterogeneity. This review article outlines the current state of osteosarcoma research with a particular focus on exome- and genome-wide sequencing analyses and potential impacts on new therapeutic opportunities.
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