Related Experiment Video
Updated: Feb 22, 2026
08:01
LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics
Published on: April 9, 2017
8.6K
L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential.
J S Metcalf1, R A Dunlop1, J T Powell1
1Brain Chemistry Labs, The Institute for Ethnomedicine, Jackson, 83001, WY, USA.
Neurotoxicity Research
|September 21, 2017
Summary
L-serine demonstrates neuroprotective effects in various models and human trials, supporting its safety and therapeutic potential for neurological disorders. It
Area of Science:
- Neuroscience
- Biochemistry
- Metabolic Disorders
Background:
- L-serine, typically non-essential, acts as a conditional non-essential amino acid.
- It is synthesized in the central nervous system and is a precursor for glycine and cysteine.
- L-serine plays crucial physiological roles, including protein phosphorylation.
Purpose of the Study:
- To explore the neuroprotective role of L-serine.
- To evaluate its potential as a therapeutic agent for neurological disorders.
Main Methods:
- Studies involved human neuroblastoma cell cultures, non-human primates, and human beings.
- Analysis of biochemical and molecular mechanisms of L-serine's action.
- Review of animal dosing and human clinical trial data.
Main Results:
- L-serine exhibits neuroprotective properties across different models.
- Human clinical trials and animal studies confirm L-serine's safety (GRAS status).
- Mutations in L-serine metabolic enzymes are linked to human diseases.
Conclusions:
- L-serine is a conditionally non-essential amino acid with significant neuroprotective capabilities.
- Its safety and therapeutic potential warrant further investigation for neurological conditions.
More Related Videos
10:18A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
Published on: April 25, 2015
10.7K
12:21Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
15.6K
Related Concept Videos
03:42Amino acids
107.4K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
107.4K
01:31Skeletal Muscle Relaxants: Therapeutic Uses
1.1K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.1K
02:30siRNA - Small Interfering RNAs
18.8K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.8K
01:21Skeletal Muscle Relaxants: Adverse Effects
930
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
930
02:30Chirality in Nature
17.4K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
17.4K
01:24Centrally Acting Muscle Relaxants: Therapeutic Uses
1.4K
Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
1.4K