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Sperm Collection of Differential Quality Using Density Gradient Centrifugation
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Association between obesity and sperm quality.

G A Ramaraju1, S Teppala1, K Prathigudupu1

  • 1Center for Assisted Reproduction, Krishna IVF Clinic, Visakhapatnam, India.

Andrologia
|September 21, 2017
PubMed
Summary
This summary is machine-generated.

Obese men exhibit significantly poorer sperm quality, including lower volume, count, motility, and velocity, along with increased head defects. This study highlights the impact of obesity on male fertility parameters.

Keywords:
CASAassisted reproductionbody mass indexobesitysemen analysis

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Area of Science:

  • Reproductive Medicine
  • Andrology
  • Sperm Analysis

Background:

  • Paternal obesity is a growing concern in reproductive health.
  • Previous studies on obesity's impact on sperm quality yielded inconclusive results.
  • Computer-aided sperm analysis (CASA) offers advanced precision in evaluating sperm parameters.

Purpose of the Study:

  • To investigate the association between obesity and specific sperm parameters using CASA.
  • To determine if obesity correlates with reduced sperm quality and increased sperm defects.
  • To provide data for clinicians considering paternal obesity in fertility assessments.

Main Methods:

  • Retrospective cohort study of 1285 men undergoing infertility assessment.
  • Utilized Computer-Aided Sperm Analysis (CASA) for detailed sperm parameter evaluation.
  • Analyzed data from 2016, comparing obese (BMI ≥30) and non-obese men.

Main Results:

  • Obesity was linked to significantly lower semen volume, sperm count, and concentration.
  • Obese men showed reduced progressive and total sperm motility, and lower average velocities (curve and path).
  • Higher percentages of abnormal sperm head shapes (defects, thin, pyriform) were observed in obese men.
  • Obesity increased the likelihood of oligospermia (low sperm count) and asthenospermia (poor motility).

Conclusions:

  • This study provides the first CASA-based evidence of abnormal sperm parameters in obese men.
  • Paternal obesity is significantly associated with multiple indicators of reduced sperm quality.
  • Clinicians should consider paternal obesity as a factor in assisted reproduction planning.