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Updated: Feb 22, 2026

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
Published on: January 16, 2020
Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors
Yan Jiang1, Chunlin Zhuang1, Long Chen1
1School of Pharmacy, Second Military Medical University , Shanghai 200433, China.
Abstract:
Structural biology is a powerful tool for investigating the stereospecific interactions between a protein and its ligand. Herein, an unprecedented chiral binding pattern was observed for inhibitors of KRAS-PDEδ interactions. Virtual screening and X-ray crystallography studies revealed that two enantiomers of a racemic inhibitor could bind at different sites. Fragment-based drug design was used to identify highly potent PDEδ inhibitors that can be used as promising lead compounds for target validation and antitumor drug development.
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