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Pelagic paralysis.

A R Mills, R Passmore

    Lancet (London, England)
    |January 23, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Seafood toxins causing puffer fish poisoning, ciguatera, and paralytic shellfish poisoning block nerve sodium channels. These conditions, clinically indistinguishable, are proposed to be named pelagic paralysis.

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    Area of Science:

    • Neuroscience
    • Toxicology
    • Marine Biology

    Background:

    • Puffer fish poisoning, ciguatera, and paralytic shellfish poisoning are distinct seafood-borne illnesses.
    • These conditions share a common mechanism of action involving voltage-gated sodium channels.

    Purpose of the Study:

    • To propose a unifying term for clinically indistinguishable seafood poisoning syndromes.
    • To highlight the shared neurotoxic mechanism of these poisonings.

    Main Methods:

    • Clinical observation and comparison of symptoms across different seafood poisonings.
    • Review of existing toxicological and neurological data on marine toxins.

    Main Results:

    • Puffer fish poisoning, ciguatera, and paralytic shellfish poisoning exhibit overlapping clinical presentations.

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  • All three conditions result from toxins that block voltage-gated sodium channels in nerves.
  • A new clinical entity, 'pelagic paralysis', is proposed to encompass these syndromes.

    • Conclusions:

    • Pelagic paralysis is a unifying concept for specific seafood poisonings with shared neurotoxicity.
    • Clinical presentation variability is attributed to differences in toxin concentration within the consumed seafood.
    • This classification aids in understanding and potentially diagnosing these neurological syndromes.