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Macrolide-Resistant Mycoplasma pneumoniae Infection, Japan, 2008-2015

Takaaki Tanaka, Tomohiro Oishi, Ippei Miyata

    Emerging Infectious Diseases
    |September 21, 2017
    PubMed

    Insights

    Macrolide-resistant Mycoplasma pneumoniae infections in Japanese children decreased significantly after 2012. This study tracked resistance trends from 2008-2015, showing a notable decline in resistant strains.

    Area of Science:

    • Pediatric infectious diseases
    • Antimicrobial resistance surveillance
    • Molecular epidemiology

    Background:

    • Mycoplasma pneumoniae is a common cause of respiratory infections in children.
    • Macrolide antibiotics are a primary treatment for M. pneumoniae infections.
    • Increasing macrolide resistance in M. pneumoniae poses a significant public health challenge.

    Purpose of the Study:

    • To analyze the prevalence and trends of macrolide-resistant Mycoplasma pneumoniae in children in Japan.
    • To evaluate the temporal changes in macrolide resistance from 2008 to 2015.

    Main Methods:

    • Isolates from children with M. pneumoniae infection were collected across Japan between 2008 and 2015.
    • Macrolide resistance patterns were determined for the collected isolates.
    • Prevalence data were analyzed to identify trends over the study period.

    Main Results:

    • The prevalence of macrolide-resistant M. pneumoniae peaked in 2012 at 81.6%.
    • Following the peak, resistance prevalence decreased to 59.3% in 2014 and 43.6% in 2015.
    • A significant downward trend in macrolide resistance was observed in the later years of the study.

    Conclusions:

    • The prevalence of macrolide-resistant Mycoplasma pneumoniae in Japanese children has shown a decreasing trend since 2012.
    • Continued surveillance is crucial to monitor antimicrobial resistance patterns in M. pneumoniae.
    • Understanding these trends can inform treatment guidelines and public health strategies.
    Keywords:
    JapanMycoplasma pneumoniaeantimicrobial resistancebacteriachildrendrug resistancemacrolidesreal-time PCR

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