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Updated: Feb 22, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes
Jianguo Liu1, Suppachai Krajangsri1, Thishana Singh1
1Department of Organic Chemistry, Stockholm University, Arrhenius-laboratory , 10691, Stockholm, Sweden.
Abstract:
A highly efficient regio- and enantioselective monohydrogenation of 1,4-dienes has been realized using an iridium catalyst with a chiral N,P-ligand under mild conditions. The substrate scope was studied and included both unfunctionalized as well as functionalized substituents on the meta- or para-position. Substrates having substituents with functionalities such as silyl protected alcohols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98% ee).
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