Related Experiment Video
Updated: Feb 22, 2026

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
Published on: August 29, 2017
Molecular evolution of hemagglutinin gene of Influenza A virus
1School of Biotechnology, Adamas University, Barasat, Kolkata 700126, WB, India, and Centre for Interdisciplinary Research and Education, Jodhpur Park, Kolkata 700068, WB, India, antaradnet@gmail.com.
Abstract:
In the history of human civilization, influenza is the second most catastrophic killer disease for mankind with plague ranking first in the medieval times. The 1918-1919 'Spanish flu' killed 20-50 million people worldwide. According to a report from WHO, there have been four pandemics, several epidemics and recurrent seasonal outbreaks of influenza in different parts of the world. The virus is a potential bioterrorism threat with biological 'Chernobyl-like disaster' that occurred in Soviet Russia in 1977. Here, the author reviews the biology of the surface exposed hemagglutinin of the influenza virus, a gene under constant positive selection pressure to evade host immunity and vaccination. Global, local and seasonal outbreaks of influenza lead to a significant number of deaths both in humans and poultry birds.
More Related Videos
10:32A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins
Published on: May 29, 2016
13:12Quantitative Analyses of all Influenza Type A Viral Hemagglutinins and Neuraminidases using Universal Antibodies in Simple Slot Blot Assays
Published on: April 4, 2011
Related Concept Videos
Viral Mutations
Leaky Scanning
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Viral Recombination
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Gene Duplication and Divergence
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...