Osteoimmunology: The Nexus between bone and immune system
Hamid Y Dar1, Zaffar Azam1, Rajaneesh Anupam2
1Osteoimmunology Lab, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar (MP)-470003, India.
Frontiers in Bioscience (Landmark Edition)
|September 21, 2017
Summary
Osteoimmunology reveals how immune cells influence bone health, impacting conditions like osteoporosis and rheumatoid arthritis. Understanding this bone-immune crosstalk offers new therapeutic strategies for inflammatory bone diseases.
Area of Science:
- Osteoimmunology
- Interdisciplinary research combining osteology and immunology.
Background:
- Inflammatory bone diseases like rheumatoid arthritis, osteoporosis, and periodontitis exhibit significant bone loss.
- Immune cells, including T helper cells (Th1, Th2, Treg, Th17), B cells, dendritic cells (DC), and macrophages, are crucial for bone homeostasis.
Purpose of the Study:
- To provide an overview of the intricate relationship between the bone and immune systems.
- To highlight the cross-communication between these systems within the bone marrow niche.
- To explore the potential for novel therapeutics targeting bone loss in inflammatory conditions.
Main Methods:
- Review of existing literature on osteoimmunology.
- Analysis of the role of immune cells in bone biology and disease.
- Examination of molecular mechanisms underlying bone-immune interactions.
Main Results:
- The bone and immune systems share a common niche (bone marrow) and actively communicate.
- Immune cells significantly influence bone homeostasis and disease pathogenesis.
- Understanding these interactions is key to developing new treatments.
Conclusions:
- Osteoimmunology is a rapidly emerging field with significant therapeutic potential.
- Molecular insights into osteoimmunology can lead to novel prevention and treatment strategies for inflammatory bone diseases.
- Targeting the bone-immune nexus offers promise for conditions like osteoporosis, rheumatoid arthritis, and osteoarthritis.
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