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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Role of fibroblast growth factor receptor-2 splicing in normal and cancer cells

Toshiyuki Ishiwata1

  • 1Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan, tishiwat@tmig.or.jp.

Frontiers in Bioscience (Landmark Edition)
|September 21, 2017
PubMed

Insights

Fibroblast growth factor receptor-2 (FGFR-2) variants, IIIb and IIIc, are key in cancer progression. Their expression and switching correlate with cancer aggressiveness, making FGFR-2 a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Fibroblast growth factor receptors (FGFRs) are implicated in various cancers.
  • FGFR-2 is a significant factor in carcinogenesis and cancer progression.
  • FGFR-2 is a potential novel therapeutic target in cancer treatment.

Purpose of the Study:

  • To discuss the expression patterns of FGFR-2 variants IIIb and IIIc in different cancers.
  • To elucidate the roles of FGFR-2 variants in cancer development and progression.
  • To explore the regulatory mechanisms governing FGFR-2 variant expression and function in cancer.

Main Methods:

  • Review of scientific literature on FGFR-2 expression and function in cancer.
  • Analysis of alternative splicing mechanisms leading to FGFR-2 IIIb and IIIc variants.
  • Examination of the correlation between FGFR-2 variant switching and epithelial-mesenchymal transition (EMT).

Main Results:

  • FGFR-2 IIIb is expressed in normal epithelial cells and numerous epithelial cancers.
  • FGFR-2 IIIc is expressed in mesenchymal cells and certain cancers, particularly during EMT.
  • Switching from FGFR-2 IIIb to IIIc correlates with increased cancer aggressiveness via EMT.

Conclusions:

  • FGFR-2 variants IIIb and IIIc exhibit distinct expression profiles in normal tissues and cancers.
  • The differential expression and switching of FGFR-2 variants play critical roles in cancer progression.
  • Understanding FGFR-2 variant regulation offers insights into targeted cancer therapies.

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