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Updated: Feb 22, 2026
08:14
Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
Published on: May 8, 2016
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Immune response to systemic inflammation in the intestinal microcirculation
Taylor Thorburn1, Maral Aali2, Christian Lehmann3
1Department of Microbiology and Immunology, Dalhousie University, Halifax NS, and Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax NS.
Frontiers in Bioscience (Landmark Edition)
|September 21, 2017
Summary
Systemic inflammation involves immune dysregulation, with the intestine playing a key role. Studying intestinal microcirculation offers insights into inflammation triggers and therapeutic targets.
Area of Science:
- Immunology and Gastroenterology
Background:
- Systemic inflammation involves immune response dysregulation, impacting organs like the intestine.
- The intestine's microcirculation is crucial, as disturbances can lead to bacterial translocation and worsen inflammation.
- Intestinal microcirculation is both a trigger and a therapeutic target in systemic inflammation.
Purpose of the Study:
- To highlight the significance of intestinal microcirculation in systemic inflammation.
- To discuss the role of intravital microscopy and novel imaging technologies in studying the microcirculation.
- To identify future directions for improving diagnostic and therapeutic monitoring of intestinal microcirculation.
Main Methods:
- Experimental intravital microscopy for in vivo study of immune responses in tissues.
- Application of novel non-invasive imaging technologies for human microcirculation examination.
Main Results:
- Intestinal microcirculation disturbances contribute to bacterial translocation and disease severity.
- Intravital microscopy provides unique in vivo insights into immune responses.
- Non-invasive imaging advances human microcirculation studies.
Conclusions:
- Intestinal microcirculation is a critical factor in systemic inflammation.
- Advanced imaging techniques are essential for understanding and managing intestinal microcirculation.
- Further technological development is needed for routine clinical application.
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