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Related Concept Videos

Aging01:26

Aging

885
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
249
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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Natural aging as as a sequential poly-systemic syndrome.

Vyacheslav N Krut'ko1, Vitaly I Dontsov2, Alexander V Khalyavkin2

  • 1Institute for Systems Analysis, Federal Research Center "Computer Science and Control", Russian Academy of Sciences, 117312 Moscow, Russia, krutkovn@mail.ru.

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|September 21, 2017
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Summary
This summary is machine-generated.

Aging can be viewed as a multi-syndrome disease, enabling better prevention, diagnosis, and treatment of age-related dysfunctions for physicians.

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Area of Science:

  • Gerontology
  • Internal Medicine
  • Pathology

Background:

  • Aging is a complex biological process.
  • Current approaches often treat aging-related dysfunctions individually.

Purpose of the Study:

  • To propose a novel framework viewing aging as a poly-syndrome disease.
  • To guide physicians in managing age-related conditions.

Main Methods:

  • Review of existing literature on aging and disease syndromes.
  • Conceptual analysis of aging progression.

Main Results:

  • Aging can be conceptualized as a sequential development of multiple syndromes.
  • This perspective aligns aging with other complex diseases.

Conclusions:

  • Viewing aging as a poly-syndrome disease facilitates a generalized approach.
  • This facilitates prevention, diagnosis, and treatment of aging-related dysfunctions.