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Updated: Feb 22, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

Transcriptomics in amyotrophic lateral sclerosis.

Marios G Krokidis¹, Panagiotis Vlamos²

¹Bioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, Corfu, Greece, and National Center for Scientific Research, m.krokidis@inn.demokritos.gr.

Frontiers in Bioscience (Elite Edition)

|September 21, 2017

Summary

This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with no cure. Transcriptomic studies reveal altered RNA metabolism and gene expression, offering potential new therapeutic targets for ALS.

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Area of Science:

Neuroscience
Genetics
Molecular Biology

Background:

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease impacting motor neurons.
The precise pathophysiological mechanisms underlying ALS remain poorly understood.
Microarray technology enables large-scale gene expression analysis, aiding disease research.

Purpose of the Study:

To review current transcriptomic evidence in ALS pathogenesis.
To identify molecular targets for novel ALS treatments.
To investigate the role of RNA metabolism dysregulation, including microRNAs and ribosomal binding proteins, in ALS.

Main Methods:

Review of transcriptomic studies in animal models and human samples.
Analysis of gene expression profiles.
Investigation of microRNA and ribosomal binding protein alterations.

Main Results:

Transcriptomic studies provide insights into ALS pathogenesis.
Altered RNA metabolism is a key dysregulated pathway in ALS.
Specific microRNA and ribosomal binding protein alterations contribute to ALS pathology.

Conclusions:

Transcriptomic data offers potential therapeutic targets for ALS.
Understanding RNA dysregulation is crucial for ALS treatment development.
Further research into molecular targets may lead to effective ALS therapies.