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Related Experiment Video

Updated: Feb 22, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

Take DAT, Flu!

Lior Lobel¹, Wendy S Garrett²

¹Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

|September 21, 2017

Summary

This summary is machine-generated.

The bacterial metabolite desaminotyrosine (DAT) enhances the immune response to influenza by boosting type I interferon. This finding helps explain how gut microbes influence infection outcomes in different individuals.

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Last Updated: Feb 22, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

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Published on: January 20, 2017

Area of Science:

Microbiology
Immunology
Infectious Disease

Background:

Microbial metabolites can modulate immune responses.
Inter-individual variability in infection response is not fully understood.
The role of specific bacterial metabolites in host immunity requires further investigation.

Purpose of the Study:

To investigate the immunomodulatory effects of microbial metabolites.
To determine the impact of desaminotyrosine (DAT) on immune responses to influenza infection.

Main Methods:

Analysis of bacterial metabolites.
Assessment of type I interferon expression.
In vivo studies of influenza infection response.

Main Results:

The bacterial metabolite desaminotyrosine (DAT) was identified.
DAT was shown to increase type I interferon expression.
Increased type I interferon expression led to an improved immune response to influenza.

Conclusions:

Desaminotyrosine (DAT) is an immunomodulatory metabolite.
DAT enhances the immune defense against influenza infection.
Microbial metabolites like DAT contribute to inter-individual variation in infection response.