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Related Experiment Videos

Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques.

Edyta Pindelska1, Agnieszka Sokal1, Waclaw Kolodziejski1

  • 1Medical University of Warsaw, Faculty of Pharmacy with the Laboratory Medicine Division, Department of Inorganic and Analytical Chemistry, Banacha 1, 02-093 Warsaw, Poland.

Advanced Drug Delivery Reviews
|September 22, 2017
PubMed
Summary
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This review details advanced analytical methods for characterizing solid drug forms, crucial for optimizing drug properties during development. These techniques ensure comprehensive analysis from bulk to molecular levels for efficient drug discovery.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Optimizing drug properties requires modifying active pharmaceutical ingredients (APIs) into forms like cocrystals, salts, or polymorphs.
  • Selecting the optimal solid form is critical for achieving desired physiochemical, pharmaceutical, and biological characteristics.

Purpose of the Study:

  • To review advanced analytical methods for characterizing solid drug forms.
  • To highlight the pharmaceutical relevance of these characterization techniques in drug development.

Main Methods:

  • Diffraction methods
  • Spectroscopic methods
  • Thermal analysis
  • Pharmaceutical characterization techniques

Main Results:

Keywords:
Active pharmaceutical ingredientCrystallographic studiesDrugNMR crystallographySolubilitySpectroscopic characterizationStabilityThermal analysis

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  • These methods enable comprehensive analysis of solid APIs, from bulk to molecular levels.
  • Information on structure, properties, purity, and transformations can be obtained.
  • In situ and real-time monitoring of physical processes during drug development is possible.

Conclusions:

  • Advanced analytical methods are essential for efficient, comprehensive characterization of solid drug forms.
  • These techniques are vital for understanding and optimizing drug properties throughout the development lifecycle.