Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Therapeutic trials in hamster dystrophy.

G Jasmin, B Solymoss, L Proschek

    Annals of the New York Academy of Sciences
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Thymic lymphosarcoma in magnesium-deficient rats.

    Biological trace element research·2013
    Same author

    Effects of mibefradil, a T- and L-type calcium channel blocker, on cardiac remodeling in the UM-X7.1 cardiomyopathic hamster.

    Cardiovascular drugs and therapy·2001
    Same author

    Age-related serum levels of insulin-like growth factor-I, -II and IGF-binding protein-3 following myocardial infarction.

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2000
    Same author

    Cardioprotective efficacy of verapamil and mibefradil in young UM-X7.1 cardiomyopathic hamsters.

    Cardiovascular drugs and therapy·2000
    Same author

    Effect of orotic acid and magnesium orotate on the development and progression of the UM-X7.1 hamster hereditary cardiomyopathy.

    Cardiovascular drugs and therapy·1998
    Same author

    Effects of phosphoramidon, BQ 788, and BQ 123 on coronary and cardiac dysfunctions of the failing hamster heart.

    Journal of cardiovascular pharmacology·1998

    Calcium channel blockers and adrenergic blockers significantly reduced heart lesions in cardiomyopathic hamsters, primarily preventing damage rather than treating advanced lesions. These drugs likely work by reducing calcium conductivity in heart cells.

    Area of Science:

    • Cardiovascular Research
    • Pharmacology
    • Cell Biology

    Background:

    • UM-X7.1 cardiomyopathic hamsters exhibit myocardial pathology.
    • Pathologic changes in the myocardium correlate with increased adrenergic nerve activity.

    Purpose of the Study:

    • To investigate the efficacy of various drugs in preventing heart lesions in a hamster model of cardiomyopathy.
    • To explore the role of calcium influx and adrenergic neurotransmission in the development of cardiac lesions.

    Main Methods:

    • Treatment of UM-X7.1 cardiomyopathic hamsters with verapamil, prenylamine, Dibenamine, propanolol, and prostaglandin E1.
    • Assessment of the severity of heart lesions in treated versus untreated hamsters.

    Main Results:

    Related Experiment Videos

  • Verapamil, prenylamine, Dibenamine, propanolol, and prostaglandin E1 markedly reduced the severity of heart lesions.
  • The beneficial effects were primarily preventive, with no protection observed for fully developed skeletal muscle lesions.

    • Conclusions:

    • Drugs antagonizing calcium influx and adrenergic receptors, as well as prostaglandin E1, show preventive efficacy against heart lesions in cardiomyopathic hamsters.
    • These drugs are believed to function mainly by decreasing calcium conductivity across cardiocyte sarcolemmal membranes, potentially by modulating adrenergic nerve activity.