Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variation in Position Effect Variegation Within a Natural Population.

Keegan J P Kelsey1, Andrew G Clark2

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 kjk86@cornell.edu.

Genetics
|September 22, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Female genetic variation controlling timing of mating plug ejection in <i>Drosophila melanogaster</i>.

bioRxiv : the preprint server for biology·2026
Same author

Comparative population genomics reveals adaptive convergence in two Drosophila species across global environments.

Cell reports·2026
Same author

Correlated gene copy number changes in a seminal fluid protein network in <i>Drosophila</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The Stellate meiotic drive system of Drosophila melanogaster is active in contemporary populations.

Genetics·2026
Same author

e3SIM: Epidemiological-ecological-evolutionary simulation framework for genomic epidemiology.

Methods in ecology and evolution·2026
Same author

Technical challenges and quality considerations for dissolving microneedles.

International journal of pharmaceutics·2026

Population genetic forces shape chromatin state. This study reveals extensive variation in position effect variegation (PEV) within a natural population, with most variance linked to novel genetic regions, not known PEV modifiers.

Area of Science:

  • Genetics
  • Epigenetics
  • Population Genetics

Background:

  • Chromatin state changes influence gene expression.
  • Understanding population genetic drivers of chromatin variation is crucial.
  • Position Effect Variegation (PEV) serves as a proxy for chromatin state.

Purpose of the Study:

  • To survey PEV variation in a natural population.
  • To explore the genetic architecture of natural variation in PEV modifiers.
  • To determine if known suppressor (Su(var)) and enhancer (E(var)) genes explain natural PEV variation.

Main Methods:

  • Utilized a dominant mapping study design.
  • Surveyed interindividual variation in PEV.
  • Analyzed genetic architecture of PEV modifiers.
Keywords:
Position Effect Variegation (PEV)chromatinenhancer of variegationnatural variationphenotypic variancesuppressor of variegation

Related Experiment Videos

Main Results:

  • Identified extensive natural variation in PEV.
  • Found that the majority of PEV variance does not map to previously identified PEV modifier genes.
  • Observed enrichment of associations near active promoters and transcription start sites.

Conclusions:

  • Natural variation in PEV is substantial within populations.
  • Segregating autosomal variants play a significant role in modifying PEV.
  • The genetic basis of PEV variation may involve novel genomic regions impacting gene regulation.