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Complex systems biology.

Avi Ma'ayan1

  • 1BD2K-LINCS Data Coordination and Integration Center; Mount Sinai Center for Bioinformatics; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA avi.maayan@mssm.edu.

Journal of the Royal Society, Interface
|September 22, 2017
PubMed
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Complex systems theory principles can illuminate human cell biology. Applying these concepts enhances understanding of normal cell function and disease development.

Area of Science:

  • Integrative biology
  • Complex systems theory
  • Cellular biology

Background:

  • Systems biology has rapidly advanced, focusing on molecular and cellular interactions.
  • The human cell is a prime example of a complex system, yet this is often overlooked.
  • Complex systems theory offers a framework for understanding diverse natural, technological, and social systems.

Purpose of the Study:

  • To outline general design principles from complex systems theory.
  • To describe the human cell as a prototypical complex system.
  • To explore how complex systems concepts can advance systems biology.

Main Methods:

  • Literature review of complex systems theory.
  • Application of systems theory principles to human cellular organization.
Keywords:
agentscomplexityevolution

Related Experiment Videos

  • Conceptual analysis integrating systems biology and complex systems theory.

    • Main Results:

    • Identified common design principles applicable to complex systems.
    • Characterized the human cell as a representative complex system.
    • Demonstrated the utility of a complex systems approach in biology.

    Conclusions:

    • Viewing the human cell through the lens of complex systems theory offers novel insights.
    • This perspective can deepen the understanding of normal cell physiology.
    • It provides a framework for investigating the molecular basis of human diseases.