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Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6

Morgan Thurman1, Jacob van Doorn1, Barbara Danzer1

  • 1University of Kentucky, Lexington, KY, USA.

Biomarker Insights
|September 22, 2017
PubMed
Summary

Sudemycin D6 alters alternative splicing in human blood lymphocytes, acting as a pharmacodynamic marker. Effects on exon skipping in DUSP11 and SRRM1 pre-mRNAs are observed starting 9 hours post-treatment.

Keywords:
Alternative splicinglymphocytes RNAsplicing inhibitionsudemycin

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