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Updated: Feb 22, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Collagen Cross- Linking for Paediatric Keratoconus
Georgios D Panos1, Nikolaos Kozeis2, Miltiadis Balidis2
1Department of Ophthalmology, Ipswich Hospital NHS Trust, University of Cambridge, Ipswich, Suffolk, UK.
Insights
Corneal crosslinking (CXL) effectively halts keratoconus progression in children, offering a vital treatment option for this age group. This review updates current literature on CXL
Area of Science:
- Ophthalmology
- Corneal Surgery
Background:
- Corneal crosslinking (CXL) has shown promise in halting keratoconus progression in adults since the late 1990s.
- Keratoconus progression is more rapid and frequent in pediatric patients, necessitating prompt and effective interventions.
Purpose of the Study:
- To review the current literature on the application of corneal crosslinking (CXL) in pediatric keratoconus patients.
- To assess the efficacy and safety of CXL as a treatment to stop or slow keratoconus progression in children.
Main Methods:
- Literature review of studies investigating corneal crosslinking in pediatric populations.
- Analysis of treatment outcomes, including efficacy in halting disease progression and safety profiles.
Main Results:
- Corneal crosslinking (CXL) has been increasingly applied to children, building on its success in adult keratoconus treatment.
- Initial findings suggest CXL is a viable option for managing pediatric keratoconus.
Conclusions:
- Corneal crosslinking (CXL) represents a significant advancement in managing pediatric keratoconus.
- Further research and long-term data are essential to fully establish CXL's role in this age group.
Background:
Since the late 1990s corneal crosslinking (CXL) has been proposed as a new treatment option which can stop progression of keratoconus with promising results in adults.
Objective:
Keratoconus presents a higher rate and faster progression in paediatric patients and for this reason prompt and effective treatment is essential. Due to its success in adult keratoconus patients, CXL has been recently applied to children in order to stop or slow progression of keratoconus in paediatric patients.
Conclusions:
This article will present an update of the literature on the topic of CXL in this age group.
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