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Related Concept Videos

Papillary Dermis01:11

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Pigmentation01:19

Pigmentation

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Updated: Feb 22, 2026

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules
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[A pink nodule on the face].

Amina Kissou1, Badredine Hassam1

  • 1Service de Dermatologie, Centre Hospitalier Universitaire Ibn Sina, Rabat, Maroc.

The Pan African Medical Journal
|September 22, 2017
PubMed
Summary
This summary is machine-generated.

A rare case of benign cellular histiocytofibroma, a skin nodule, was diagnosed in a 32-year-old woman. Surgical resection led to a complete recovery with no recurrence after two years.

Keywords:
Nodulefacehistiocytofibroma

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Benign cellular histiocytofibroma is a rare skin tumor, typically affecting middle-aged women.
  • It usually presents as a firm, often asymptomatic, dermal nodule on the lower limbs.

Observation:

  • A 32-year-old female presented with a 10-year history of a right cheek nodule.
  • Clinical examination revealed a 1cm reddish, smooth-surfaced dermal nodule.
  • Skin biopsy showed fusiform cell proliferation with positive CD68 and negative CD34, PS100, and AML markers.

Findings:

  • The diagnosis of benign cellular histiocytofibroma was confirmed through histopathology and immunohistochemistry.
  • The patient underwent successful surgical resection with clear margins.
  • A 2-year follow-up showed no signs of recurrence.

Implications:

  • This case highlights the importance of considering benign cellular histiocytofibroma in the differential diagnosis of facial skin nodules.
  • Complete surgical excision is an effective treatment, ensuring favorable prognosis.
  • Further research into rare presentations and locations of histiocytofibromas is warranted.