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Related Experiment Video

Updated: Feb 22, 2026

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Cardiovascular involvement in celiac disease.

Edward J Ciaccio1, Suzanne K Lewis1, Angelo B Biviano2

  • 1Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States.

World Journal of Cardiology
|September 22, 2017
PubMed
Summary
This summary is machine-generated.

Celiac disease (CD) is linked to various cardiovascular issues. A gluten-free diet (GFD) often resolves these problems, but some may be irreversible, necessitating CD screening for unexplained heart conditions.

Keywords:
CardiovascularCeliac diseaseGlutenHeartVascular

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Area of Science:

  • Gastroenterology
  • Cardiology
  • Immunology

Background:

  • Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion, causing intestinal and systemic manifestations.
  • Cardiovascular system alterations in untreated CD have garnered increasing research interest.
  • A gluten-free diet (GFD) is the primary treatment for CD, typically leading to symptom resolution.

Purpose of the Study:

  • To review and categorize published studies examining the relationship between celiac disease and cardiovascular conditions.
  • To identify trends in research on CD and cardiovascular manifestations over time.
  • To summarize the types of cardiovascular issues associated with CD and their response to treatment.

Main Methods:

  • Systematic review of studies with "celiac disease" and "cardiovascular" terms in the title.
  • Categorization of publications by type (articles, reviews, case studies, etc.) and focus (heart or vascular).
  • Data compilation on publication year, study type, and specific cardiovascular conditions linked to CD.

Main Results:

  • A significant increase in CD-cardiovascular studies since 2000, primarily articles and case studies.
  • Cardiomyopathy was the most studied condition (33 studies), followed by thrombosis (27), cardiovascular risk (17), and atherosclerosis (13).
  • Most cardiovascular issues in untreated CD patients resolve with a GFD and intestinal healing, though some alterations can be permanent.

Conclusions:

  • Untreated celiac disease is associated with a range of cardiovascular complications.
  • A gluten-free diet is effective in resolving many CD-related cardiovascular issues.
  • Screening for celiac disease is crucial when unexplained cardiovascular conditions arise, as early treatment can prevent irreversible damage.