Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pediatric lung transplantation.

Christian Benden1

  • 1Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Journal of Thoracic Disease
|September 22, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Society for Heart and Lung Transplantation Scientific Statement on pulmonary antibody-mediated rejection and proposed graft, antibody, and pathology (GAP) definition.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Pediatric lung transplantation in 2026: recent changes and current challenges.

Current opinion in organ transplantation·2026
Same author

Addressing Healthcare Disparities in Pediatric Thoracic Transplantation: A Blueprint for Change.

Pediatric transplantation·2026
Same author

Quality of Life Measures in Pediatric Lung Transplantation.

Pediatric pulmonology·2026
Same author

A Perspective on Referral and Selection for Pediatric Lung Transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2025
Same author

Traces of the transplantation complex in Jean-Luc Nancy's body-ontological work.

The International journal of psycho-analysis·2025
Same journal

From contraindication to consideration: the role of esophagectomy in stage IV esophageal adenocarcinoma.

Journal of thoracic disease·2026
Same journal

Clinical features and prognostic factor of small (≤2 cm) lung cancer associated with cystic airspaces.

Journal of thoracic disease·2026
Same journal

Sex-specific trends in incidence and mortality of interstitial lung disease and pulmonary sarcoidosis in China compared with global estimates, 1990-2023: an analysis of GBD 2023.

Journal of thoracic disease·2026
Same journal

A single-arm, single-center phase II clinical study of concurrent brain radiotherapy combined with tislelizumab and chemotherapy in patients with small-cell lung cancer and brain metastases.

Journal of thoracic disease·2026
Same journal

Minimally invasive off-pump coronary artery bypass grafting is associated with reduced postoperative intra-aortic balloon pump use.

Journal of thoracic disease·2026
Same journal

Pulmonary artery involvement contributes to the recurrence of hemoptysis after bronchial artery embolization in patients with chronic pulmonary aspergillosis.

Journal of thoracic disease·2026
See all related articles

Pediatric lung transplantation offers survival benefits for children with end-stage lung disease. Personalized immunosuppression and early intervention are key to managing challenges like infections and chronic lung allograft dysfunction (CLAD).

Area of Science:

  • Pediatric Pulmonology
  • Transplantation Surgery
  • Immunology

Background:

  • Pediatric lung transplantation has evolved since the 1980s into an accepted therapy for end-stage pulmonary diseases in children.
  • It offers selected pediatric patients significant survival benefits and improved quality of life.
  • Over 100 pediatric lung transplants are performed globally each year.

Purpose of the Study:

  • To review specific pediatric aspects of lung transplantation, including surgical challenges and immunosuppression effects on the developing immune system.
  • To provide an update on managing pediatric lung transplant recipients and outline future challenges.
  • To emphasize that children are not merely small adults in the context of transplantation.

Main Methods:

  • Review of current literature and clinical practices in pediatric lung transplantation.
Keywords:
Childrencystic fibrosis (CF)lung transplantationpediatrics

Related Experiment Videos

  • Analysis of indications, surgical considerations, immunosuppression strategies, and infectious complications.
  • Discussion of age-specific and regional variations in primary diagnoses for transplantation.

    • Main Results:

    • Indications for pediatric lung transplantation differ from adults, with cystic fibrosis (CF) being common, but vary by age and region.
    • Early referral, careful selection, and timely listing are critical for survival benefits.
    • Immunosuppression side effects, particularly renal damage, are common; tailored, personalized therapy and therapeutic drug monitoring are essential.

    Conclusions:

    • Infectious complications are frequent, contributing to nearly 50% of deaths within the first year post-transplant.
    • Chronic lung allograft dysfunction (CLAD) remains the primary barrier to long-term survival.
    • Personalized immunosuppression strategies are vital to mitigate side effects and improve outcomes in pediatric lung transplant recipients.