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Differential effects of selective brain lesions on hypothalamic and pituitary ir-dynorphin
S Spampinato1, S Candeletti, E Cavicchini
1Institute of Pharmacology, University of Bologna, Italy.
Abstract:
Selective radiofrequency and neurotoxic lesions of the serotonergic pathways caused in the rat a significant reduction of ir-dynorphin A and B in the hypothalamus but not at pituitary level. These data confirm that dynorphin-related peptides are regulated independently in these areas.