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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii)
1Department of Chemistry, King's College London, London, SE1 1DB, UK. kogularamanan.suntharalingam@kcl.ac.uk.
Dalton Transactions (Cambridge, England : 2003)
|September 22, 2017
Abstract:
Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.