Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self-assembled clusters of patchy rod-like molecules.

Miroslav Jurásek1, Robert Vácha1

  • 1CEITEC - Central European Institute of Technology, Kamenice 5, 625 00 Brno, Czech Republic and Faculty of Science, Masaryk University, Kotlářská 2, 602 00 Brno, Czech Republic. robert.vacha@mail.muni.cz robertvacha@gmail.com.

Soft Matter
|September 22, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structures of asymmetric particles of tick-borne encephalitis virus provide insight into flavivirus assembly and maturation.

Science advances·2026
Same author

Correction to "Martini 3 Limitations in Phospholipid Flip-Flop".

Journal of chemical theory and computation·2026
Same author

Martini 3 Limitations in Phospholipid Flip-Flop.

Journal of chemical theory and computation·2025
Same author

A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells.

The Journal of cell biology·2025
Same author

Role of Divalent Ions in Membrane Models of Polymyxin-Sensitive and Resistant Gram-Negative Bacteria.

Journal of chemical information and modeling·2025
Same author

Free Energy of Membrane Pore Formation and Stability from Molecular Dynamics Simulations.

Journal of chemical information and modeling·2025

Designing self-assembling structures is complex. This study reveals how attractive patch size and geometry on rod-like particles dictate aggregate formation, aiding in building block design.

Area of Science:

  • Colloid and Interface Science
  • Computational Chemistry
  • Materials Science

Background:

  • Designing self-assembled structures is challenging due to complex structure-property relationships.
  • Understanding how building block properties influence aggregate morphology is crucial for materials design.

Purpose of the Study:

  • To investigate the relationship between building block properties and self-assembled aggregate morphology.
  • To explore the formation of finite aggregates using rod-like particles with attractive patches.
  • To develop structure diagrams for predicting and extrapolating system composition.

Main Methods:

  • Utilized a combination of computer simulations and analytical theory.
  • Investigated the formation of finite aggregates under various conditions.

Related Experiment Videos

  • Constructed phase diagrams to map aggregate formation.

    • Main Results:

    • Aggregate size is primarily determined by the size and geometric arrangement of attractive patches.
    • Achieving high yields of clusters with more than four particles is difficult without complex building blocks.
    • Particles near structure boundaries exhibit sensitivity to small changes in conditions, enabling state switching.

    Conclusions:

    • The study provides a framework for understanding and designing self-assembling systems based on particle patch properties.
    • Findings are applicable to the development of novel self-assembling building blocks.
    • The research offers insights into the principles governing protein folds, such as coiled coils.